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Article

Recruitment of DNA polymerase eta by FANCD2 in the early response to DNA damage.

Cell cycle (Georgetown, Tex.) - 1 Mar 2013

Fu Dechen, Dudimah Fred Duafalia, Zhang Jun, Pickering Anna, Paneerselvam Jayabal, Palrasu Manikandan, Wang Hong, Fei Peiwen

Abstract excerpt

How Fanconi anemia (FA) protein D2 (FANCD2) performs DNA damage repair remains largely elusive. We report here that translesion synthesis DNA polymerase (pol) eta is a novel mediator of FANCD2 function. We found that wild type (wt) FANCD2, not K561R (mt) FANCD2, can interact with pol eta. Upon DNA damage, the interaction of pol eta with FANCD2 occurs earlier than that with PCNA, which is in concert with our...

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Source

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Identifiers

PMID: 23388460
DOI: 10.4161/cc.23755
PMCID: PMC3610727

Genes

FANCD2
PCNA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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