Absence of alpha-1-antitrypsin (Pi Null Bellingham) and the early onset of emphysema.

doi:10.1111/j.1445-5994.1994.tb02170.x

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Article

Absence of alpha-1-antitrypsin (Pi Null Bellingham) and the early onset of emphysema.

Australian and New Zealand journal of medicine - 1 Jun 1994

Cook L, Janus E D, Brenton S, Tai E, Burdon J

Abstract excerpt

BACKGROUND: Alpha-1-antitrypsin is the body's major inhibitor of human neutrophil elastase, a powerful proteolytic enzyme capable of degrading the common tissue components. There are over 70 genetic variants of alpha-1-antitrypsin, with the Z allele being of greatest clinical relevance. Individua...

Topics

Adult
Base Sequence
Humans
Male
Molecular Sequence Data
Pedigree
Phenotype
Pulmonary Emphysema
Respiratory Function Tests
alpha 1-Antitrypsin
alpha 1-Antitrypsin Deficiency

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