Article

Phylogenetic analysis reveals how selection and mutation shape the coevolution of mRNA and protein abundances

2024-07-11

Abstract excerpt

The regulatory mechanisms that shape mRNA and protein abundances are intensely studied. Much less is known about the evolutionary processes that shape the relationship between these two levels of gene expression. To disentangle the contributions of mutational and selective processes, we derive a novel phylogenetic model and fit it to multi-species data from mammalian skin tissue. We find that over macroevolutionar...

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Literature Corpus work: 6a4263e7-9b00-54fd-8b9d-f003c6ae5b35
DOI: 10.1101/2024.07.08.602411

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