Article
A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex.
Molecular and cellular biology - 1 Apr 2013
Armour Sean M, Bennett Eric J, Braun Craig R, Zhang Xiao-Yong, McMahon Steven B, Gygi Steven P, Harper J Wade, Sinclair David A
Abstract excerpt
Although many functions and targets have been attributed to the histone and protein deacetylase SIRT1, a comprehensive analysis of SIRT1 binding proteins yielding a high-confidence interaction map has not been established. Using a comparative statistical analysis of binding partners, we have assembled a high-confidence SIRT1 interactome. Employing this method, we identified the deubiquitinating enzyme...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.