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Article

MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC

1 Aug 2023

Abstract excerpt

Mammalian sirtuin 6 (SIRT6) regulates a spectrum of vital biological processes and has long been implicated in the progression of cancer. However, the mechanisms underlying the regulation of SIRT6 in tumorigenesis remain elusive. Here, we report that the tumor-suppressive function of SIRT6 in non-small cell lung cancer (NSCLC) is regulated by acetylation. Specifically, males absent on the first (MOF) acetylates...

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Identifiers

PMID: 37566546
DOI: 10.1016/j.celrep.2023.112939

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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