Article
Prostaglandin E2 inhibits elastogenesis in the ductus arteriosus via EP4 signaling.
Circulation - 28 Jan 2014
Yokoyama Utako, Minamisawa Susumu, Shioda Aki, Ishiwata Ryo, Jin Mei-Hua, Masuda Munetaka, Asou Toshihide, Sugimoto Yukihiko, Aoki Hiroki, Nakamura Tomoyuki, Ishikawa Yoshihiro
Abstract excerpt
BACKGROUND: Elastic fiber formation begins in mid-gestation and increases dramatically during the last trimester in the great arteries, providing elasticity and thus preventing vascular wall structure collapse. However, the ductus arteriosus (DA), a fetal bypass artery between the aorta and pulmonary artery, exhibits lower levels of elastic fiber formation, which promotes vascular collapse and subsequent closure...
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