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Article

Positional effects of presenilin-1 mutations on tau phosphorylation in cortical plaques.

Neurobiology of disease - 1 Feb 2004

Shepherd Claire E, Gregory Gillian C, Vickers James C, Brooks William S, Kwok John B J, Schofield Peter R, Kril Jillian J, Halliday Glenda M

Abstract excerpt

Mutations in presenilin-1 (PS-1) account for the majority of familial Alzheimer's disease (AD). While increasing Abeta42 is one mechanism whereby PS-1 mutations are thought to exert their pathogenic effect, little is known about the role of tau in PS-1 AD. This study compares staining (AT8 and tau-2), morphology and quantity of tau-immunoreactive cortical plaques in six PS-1 and five sporadic AD cases. The...

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Identifiers

PMID: 14751776
DOI: 10.1016/j.nbd.2003.10.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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