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Article

Variability in the type and layer distribution of cortical Aβ pathology in familial Alzheimer's disease.

Brain pathology (Zurich, Switzerland) - 1 May 2022

Willumsen Nanet, Poole Teresa, Nicholas Jennifer M, Fox Nick C, Ryan Natalie S, Lashley Tammaryn

Abstract excerpt

Familial Alzheimer's disease (FAD) is caused by autosomal dominant mutations in the PSEN1, PSEN2 or APP genes, giving rise to considerable clinical and pathological heterogeneity in FAD. Here we investigate variability in clinical data and the type and distribution of Aβ pathologies throughout the cortical layers of different FAD mutation cases. Brain tissue from 20 FAD cases [PSEN1 pre-codon 200 (n = 10), PSEN1...

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Identifiers

PMID: 34319632
DOI: 10.1111/bpa.13009
PMCID: PMC9048809

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