Article
Autophagy deficiency in beta cells leads to compromised unfolded protein response and progression from obesity to diabetes in mice.
Diabetologia - 1 Feb 2012
Quan W, Hur K Y, Lim Y, Oh S H, Lee J-C, Kim K H, Kim G H, Kim S-W, Kim H L, Lee M-K, Kim K-W, Kim J, Komatsu M, Lee M-S
Abstract excerpt
AIMS/HYPOTHESIS: The unfolded protein response (UPR) in endoplasmic reticulum (ER) and autophagy are known to be related. We investigated the role of autophagy in UPR of pancreatic beta cells and the susceptibility of autophagy-deficient beta cells to the ER stress that is implicated in the development of diabetes. METHODS: Rat insulin promoter (RIP)-Cre(+);autophagy-related 7 (Atg7)(F/W) mice were bred with ob/w...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.