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Article

Role of autophagy in <i>β</i> ‐cell function and mass

1 Oct 2010

Abstract excerpt

Type 2 diabetes (T2D) is characterized by decreased insulin secretion and action. Decreased insulin secretion results from a reduction in pancreatic β-cell mass and/or function. Apoptosis, oxidative stress, mitochondrial dysfunction and endoplasmic reticulum (ER) stress responses including JNK activation have been suggested as mechanisms for the changes of pancreatic β-cells in T2D; however, the underlying causes...

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Share to Autophagy in Disease and Therapy
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PMID: 21029296
DOI: 10.1111/j.1463-1326.2010.01278.x

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