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Article

Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes.

Diabetes - 1 Apr 2013

Bachar-Wikstrom Etty, Wikstrom Jakob D, Ariav Yafa, Tirosh Boaz, Kaiser Nurit, Cerasi Erol, Leibowitz Gil

Abstract excerpt

Accumulation of misfolded proinsulin in the β-cell leads to dysfunction induced by endoplasmic reticulum (ER) stress, with diabetes as a consequence. Autophagy helps cellular adaptation to stress via clearance of misfolded proteins and damaged organelles. We studied the effects of proinsulin misfolding on autophagy and the impact of stimulating autophagy on diabetes progression in Akita mice, which carry a...

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Identifiers

PMID: 23274896
DOI: 10.2337/db12-1474
PMCID: PMC3609555

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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