Article
Making sense of intratumor genetic heterogeneity: altered frequency of androgen receptor CAG repeat length variants in breast cancer tissues.
Human mutation - 1 Apr 2013
Gottlieb Bruce, Alvarado Carlos, Wang Chunlin, Gharizadeh Baback, Babrzadeh Farbod, Richards Brent, Batist Gerald, Basik Mark, Beitel Lenore K, Trifiro Mark
Abstract excerpt
To examine the significance of intratumor genetic heterogeneity (ITGH) of the androgen receptor (AR) gene in breast cancer, patient-matched samples of laser capture microdissected breast tumor cells, adjacent normal breast epithelia cells, and peripheral blood leukocytes were sequenced using a novel next generation sequencing protocol. This protocol measured the frequency of distribution of a variable AR CAG...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.