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Article

Genetic heterogeneity by comparative genomic hybridization in BRCAx breast cancers.

Cancer genetics and cytogenetics - 15 Apr 2008

Mangia Anita, Chiarappa Patrizia, Tommasi Stefania, Chiriatti Annalisa, Petroni Stella, Schittulli Francesco, Paradiso Angelo

Abstract excerpt

The chromosomal changes in eight familial BRCAx breast cancers (i.e., negative for BRCA1 or BRCA2) were analyzed by comparative genomic hybridization (CGH) to investigate intratumor heterogeneity. This was the first step in a study of most frequent chromosomal aberrations in BRCAx familial breast cancers. Laser microdissection analysis of paraffin tissue samples was followed by whole-genome amplification. CGH was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18406868
DOI: 10.1016/j.cancergencyto.2008.01.002

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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