Article
Heterogenous effect of androgen receptor CAG tract length on testicular germ cell tumor risk: shorter repeats associated with seminoma but not other histologic types.
Carcinogenesis - 1 Aug 2011
Davis-Dao Carol A, Siegmund Kimberly D, Vandenberg David J, Skinner Eila C, Coetzee Gerhard A, Thomas Duncan C, Pike Malcolm C, Cortessis Victoria K
Abstract excerpt
Increasing rates of testicular germ cells tumors (TGCTs) overtime suggest that environmental factors are involved in disease etiology, but familial risk and genome-wide association studies implicate genetic factors as well. We investigated whether variation in the functional CAG(n) polymorphism in the androgen receptor (AR) gene is associated with TGCT risk, using data from a population-based family study. We...
Topics
- Adult
- Biomarkers, Tumor
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- Mothers
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Prognosis
- Receptors, Androgen
- Repetitive Sequences, Nucleic Acid