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Article

Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling.

The Journal of clinical investigation - 1 Mar 2013

Funai Katsuhiko, Song Haowei, Yin Li, Lodhi Irfan J, Wei Xiaochao, Yoshino Jun, Coleman Trey, Semenkovich Clay F

Abstract excerpt

Exogenous dietary fat can induce obesity and promote diabetes, but endogenous fat production is not thought to affect skeletal muscle insulin resistance, an antecedent of metabolic disease. Unexpectedly, the lipogenic enzyme fatty acid synthase (FAS) was increased in the skeletal muscle of mice with diet-induced obesity and insulin resistance. Skeletal muscle-specific inactivation of FAS protected mice from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Sarcoplasmic Reticulum Calcium-Transporting ATPases

Source

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Identifiers

PMID: 23376793
DOI: 10.1172/JCI65726
PMCID: PMC3582136

Genes

FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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