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Article

Intramuscular diacylglycerol accumulates with acute hyperinsulinemia in insulin-resistant phenotypes.

American journal of physiology. Endocrinology and metabolism - 1 Aug 2024

McKenna Colleen F, Stierwalt Harrison D, Zemski Berry Karin A, Ehrlicher Sarah E, Robinson Matthew M, Zarini Simona, Kahn Darcy E, Snell-Bergeon Janet K, Perreault Leigh, Bergman Bryan C, Newsom Sean A

Abstract excerpt

Elevated skeletal muscle diacylglycerols (DAGs) and ceramides can impair insulin signaling, and acylcarnitines (acylCNs) reflect impaired mitochondrial fatty acid oxidation, thus, the intramuscular lipid profile is indicative of insulin resistance. Acute (i.e., postprandial) hyperinsulinemia has been shown to elevate lipid concentrations in healthy muscle and is an independent risk factor for type 2 diabetes...

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Identifiers

PMID: 38895980
DOI: 10.1152/ajpendo.00368.2023
PMCID: PMC11427097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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