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Article

Gender differences in brain susceptibility to oxidative stress are mediated by levels of paraoxonase-2 expression.

Free radical biology & medicine - 1 May 2013

Giordano G, Tait L, Furlong C E, Cole T B, Kavanagh T J, Costa L G

Abstract excerpt

Paraoxonase 2 (PON2), a member of a gene family that also includes PON1 and PON3, is expressed in most tissues, including the brain. In mouse brain, PON2 levels are highest in dopaminergic areas (e.g., striatum) and are higher in astrocytes than in neurons. PON2 is primarily located in mitochondria and exerts a potent antioxidant effect, protecting mouse CNS cells against oxidative stress. The aim of this study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23376469
DOI: 10.1016/j.freeradbiomed.2013.01.019
PMCID: PMC3622778

Genes

PON2
PON1
PON3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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