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Estradiol<i>In Vivo</i>Regulation of Brain Mitochondrial Proteome

19 Dec 2007

Abstract excerpt

We used a combined proteomic and functional biochemical approach to determine the overall impact of 17beta-estradiol (E2) on mitochondrial protein expression and function. To elucidate mitochondrial pathways activated by E2 in brain, two-dimensional (2D) gel electrophoresis was conducted to screen the mitoproteome. Ovariectomized adult female rats were treated with a single injection of E2. After 24 h of E2...

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PMID: 18094246
DOI: 10.1523/jneurosci.4391-07.2007

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