Article
The influence of mixed HCMV UL97 wildtype and mutant strains on ganciclovir susceptibility in a cell associated plaque reduction assay.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 May 2004
Eckle Tobias, Jahn Gerhard, Hamprecht Klaus
Abstract excerpt
BACKGROUND: Ganciclovir (GCV) resistance is an emerging problem following organ transplantation. A restriction fragment length polymorphism (RFLP) assay is a convenient and rapid method to discover known resistance mutations within the UL97 (phosphotransferase) gene for the determination of GCV resistance. Phenotypic resistance testing remains important for the identification of human cytomegalovirus (HCMV)...
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