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Article

V101L of human formyl peptide receptor 1 (FPR1) increases receptor affinity and augments the antagonism mediated by cyclosporins.

The Biochemical journal - 15 Apr 2013

Zhou Caihong, Zhou Yan, Wang Jia, Feng Yang, Wang Haonan, Xue Jinglun, Chen Yani, Ye Richard D, Wang Ming-Wei

Abstract excerpt

Genetic variation plays a major role in drug response variability. CsA (cyclosporin A), a widely used immunosuppressive agent, is a specific antagonist for FPR1 (formyl peptide receptor 1), which is an important G-protein-coupled chemoattractant receptor in the innate immune system. In order to study the variable responses of cyclosporins to different FPR1 mutants, we investigated the distribution of human FPR1...

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Identifiers

PMID: 23373827
DOI: 10.1042/BJ20121839
PMCID: PMC3632010

Genes

FPR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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