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Article

Functional mechanisms of MYRF DNA-binding domain mutations implicated in birth defects.

The Journal of biological chemistry - 1 Jan 2000

Fan Chuandong, An Hongjoo, Sharif Mohamed, Kim Dongkyeong, Park Yungki

Abstract excerpt

Myrf is a pleiotropic membrane-bound transcription factor that plays critical roles in diverse organisms, including in oligodendrocyte differentiation, embryonic development, molting, and synaptic plasticity. Upon autolytic cleavage, the Myrf N-terminal fragment enters the nucleus as a homo-trimer and functions as a transcription factor. Homo-trimerization is essential for this function because it imparts...

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Identifiers

PMID: 33798553
DOI: 10.1016/j.jbc.2021.100612
PMCID: PMC8094900

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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