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Article

Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity.

Cancer cell - 1 Jun 2007

Liu Yizhou, Chen Wei, Gaudet Justin, Cheney Matthew D, Roudaia Liya, Cierpicki Tomasz, Klet Rachel C, Hartman Kari, Laue Thomas M, Speck Nancy A, Bushweller John H

Abstract excerpt

AML1/ETO results from the t(8;21) associated with 12%-15% of acute myeloid leukemia. The AML1/ETO MYND domain mediates interactions with the corepressors SMRT and N-CoR and contributes to AML1/ETO's ability to repress proliferation and differentiation of primary bone marrow cells as well as to enhance their self renewal in vitro. We solved the solution structure of the MYND domain and show it to be structurally...

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Share to Bone Marrow Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Core Binding Factor Alpha 2 Subunit

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Share to Oncogene Proteins, Fusion

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Share to RUNX1 Translocation Partner 1 Protein

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Identifiers

PMID: 17560331
DOI: 10.1016/j.ccr.2007.04.010
PMCID: PMC1978186

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Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity.PMID 17560331Read ↗

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