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Article

Hedgehog signaling in neonatal and adult lung.

American journal of respiratory cell and molecular biology - 1 Jun 2013

Liu Li, Kugler Matthias C, Loomis Cynthia A, Samdani Rashmi, Zhao Zhicheng, Chen Gregory J, Brandt Julia P, Brownell Isaac, Joyner Alexandra L, Rom William N, Munger John S

Abstract excerpt

Sonic Hedgehog (Shh) signaling is essential during embryonic lung development, but its role in postnatal lung development and adult lung are not known. Using Gli1(nlacZ) reporter mice to identify cells with active Hh signaling, we found that Gli1(nlacZ)-positive mesenchymal cells are densely and diffusely present up to 2 weeks after birth and decline in number thereafter. In adult mice, Gli1(nlacZ)-positive cells...

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Identifiers

PMID: 23371063
DOI: 10.1165/rcmb.2012-0347OC
PMCID: PMC3727871

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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