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Hedgehog Signaling Pathway Orchestrates Human Lung Branching Morphogenesis

9 May 2022

Abstract excerpt

The Hedgehog (HH) signaling pathway plays an essential role in mouse lung development. We hypothesize that the HH pathway is necessary for branching during human lung development and is impaired in pulmonary hypoplasia. Single-cell, bulk RNA-sequencing data, and human fetal lung tissues were analyzed to determine the spatiotemporal localization of HH pathway actors. Distal human lung segments were cultured in an...

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PMID: 35563656
DOI: 10.3390/ijms23095265

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