Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human Natural Killer cell expression of ULBP2 is associated with a mature functional phenotype.

Human immunology - 1 Oct 2016

Brennan Kiva, McSharry Brian P, Keating Sinéad, Petrasca Andreea, O'Reilly Vincent P, Keane Joseph, Doherty Derek G, Gardiner Clair M

Abstract excerpt

NKG2D is an important activating receptor expressed on NK cells. Ligands (termed NKG2DL) for this receptor include ULBP1-6, MICA and MICB in humans; they are upregulated in stressed, cancerous or infected cells where they engage NKG2D to induce NK cell cytotoxicity and cytokine production. Expression of NKG2DL on effector cells has been described in mice and more recently in human cells. We confirm that NK cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD57 Antigens
Share to Cytotoxicity, Immunologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GPI-Linked Proteins

Share to Intercellular Signaling Peptides and Proteins

Share to Interleukin-2

Share to Killer Cells, Natural

Share to Lymphocyte Activation

Share to NK Cell Lectin-Like Receptor Subfamily K

Source

Identifiers

PMID: 27349945
DOI: 10.1016/j.humimm.2016.06.018

Genes

ULBP2
MICA
MICB
ULBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human Natural Killer cell expression of ULBP2 is associated with a mature functional phenotype.PMID 27349945Read ↗

Human NKG2D-ligands: cell biology strategies to ensure immune recognitionSemantic proximity Read ↗

IRF2 is required for development and functional maturation of human NK cellsSemantic proximity Read ↗

Advances in NKG2D ligand recognition and responses by NK cellsSemantic proximity Read ↗

Human NK cell receptors/markers: a tool to analyze NK cell development, subsets and function.Semantic proximity Read ↗

Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56bright subsetSemantic proximity Read ↗

The Biological Influence and Clinical Relevance of Polymorphism Within the NKG2D LigandsSemantic proximity Read ↗

Peripheral NK cell phenotypes: multiple changing of faces of an adapting, developing cell.Semantic proximity Read ↗

A Truncated Human NKG2D Splice Isoform Negatively Regulates NKG2D-Mediated FunctionSemantic proximity Read ↗

NK cell terminal differentiation: correlated stepwise decrease of NKG2A and acquisition of KIRs.Semantic proximity Read ↗

KIR2DL4 is an IL-2-regulated NK cell receptor that exhibits limited expression in humans but triggers strong IFN-gamma production.Semantic proximity Read ↗

Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells.Semantic proximity Read ↗

Human NKG2E is expressed and forms an intracytoplasmic complex with CD94 and DAP12.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.