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Article

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin.

EMBO molecular medicine - 1 Mar 2013

Simic Petra, Zainabadi Kayvan, Bell Eric, Sykes David B, Saez Borja, Lotinun Sutada, Baron Roland, Scadden David, Schipani Ernestina, Guarente Leonard

Abstract excerpt

Mesenchymal stem cells (MSCs) are multi-potent cells that can differentiate into osteoblasts, adipocytes, chondrocytes and myocytes. This potential declines with aging. We investigated whether the sirtuin SIRT1 had a function in MSCs by creating MSC specific SIRT1 knock-out (MSCKO) mice. Aged MSCKO mice (2.2 years old) showed defects in tissues derived from MSCs; i.e. a reduction in subcutaneous fat, cortical...

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Source

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Identifiers

PMID: 23364955
DOI: 10.1002/emmm.201201606
PMCID: PMC3598082

Genes

SIRT1
MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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