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Article

Defects in mesenchymal stem cell self-renewal and cell fate determination lead to an osteopenic phenotype in Bmi-1 null mice.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Mar 2010

Zhang Heng-Wei, Ding Jiong, Jin Jian-Liang, Guo Jian, Liu Jing-Ning, Karaplis Andrew, Goltzman David, Miao Dengshun

Abstract excerpt

In parathyroid hormone-related protein 1-84 [PTHrP(1-84)] knockin mice, expression of the polycomb protein Bmi-1 is reduced and potentially can mediate the phenotypic alterations observed. We have therefore now examined the skeletal phenotype of Bmi-1(-/-) mice in vivo and also assessed the function of bone marrow mesenchymal stem cells (BM-MSCs) from Bmi-1(-/-) mice ex vivo in culture. Neonatal Bmi-1(-/-) mice...

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PMID: 19653817
DOI: 10.1359/jbmr.090812

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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