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Article

Modeling of lamin A/C mutation premature cardiac aging using patient‐specific induced pluripotent stem cells.

Aging - 1 Nov 2012

Siu Chung-Wah, Lee Yee-Ki, Ho Jenny Chung-Yee, Lai Wing-Hon, Chan Yau-Chi, Ng Kwong-Man, Wong Lai-Yung, Au Ka-Wing, Lau Yee-Man, Zhang Jinqiu, Lay Kenneth Weijian, Colman Alan, Tse Hung-Fat

Abstract excerpt

AIMS: We identified an autosomal dominant non‐sense mutation (R225X) in exon 4 of the lamin A/C (LMNA) gene in a Chinese family spanning 3 generations with familial dilated cardiomyopathy (DCM). In present study, we aim to generate induced pluripotent stem cells derived cardiomyocytes (iPSC‐CMs) from an affected patient with R225X and another patient bearing LMNA frame‐shift mutation for drug screening. METHODS...

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Source

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Identifiers

PMID: 23362510
DOI: 10.18632/aging.100503
PMCID: PMC3560431

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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