Article

Induced pluripotent stem cells technology for investigating familial dilated cardiomyopathy due to lamin A/C mutations

2019-01-01

Abstract excerpt

Mutations of <i>LMNA</i> gene, encoding the proteins Lamin A and C, are common causes of familial dilated cardiomyopathy (DCM), typically manifesting in association with cardiac conduction defects. LaminA/C regulate various nuclear functions, including gene transcription and chromatin organization. Most of human studies on LaminA/C so far were conducted on fibroblasts, while those focusing on cardiomyocytes (CMs)...

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Literature Corpus work: e2919bba-572e-55a4-8526-3ebd74933aaa
DOI: 10.21954/ou.ro.0000f542

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