Article
Generation of induced pluripotent stem cell lines from 3 distinct laminopathies bearing heterogeneous mutations in lamin A/C.
Aging - 1 Apr 2011
Ho Jenny C Y, Zhou Ting, Lai Wing-Hon, Huang Yinghua, Chan Yau-Chi, Li Xingyan, Wong Navy L Y, Li Yanhua, Au Ka-Wing, Guo Dongsheng, Xu Jianyong, Siu Chung-Wah, Pei Duanqing, Tse Hung-Fat, Esteban Miguel Angel
Abstract excerpt
The term laminopathies defines a group of genetic disorders caused by defects in the nuclear envelope, mostly the lamins. Lamins are the main constituents of the nuclear lamina, a filamentous meshwork associated with the inner nuclear membrane that provides mechanical stability and plays important roles in processes such as transcription, DNA replication and chromatin organization. More than 300 mutations inlamin...
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