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Article

Investigating LMNA-Related Dilated Cardiomyopathy Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

International journal of molecular sciences - 23 Jul 2021

Shemer Yuval, Mekies Lucy N, Ben Jehuda Ronen, Baskin Polina, Shulman Rita, Eisen Binyamin, Regev Danielle, Arbustini Eloisa, Gerull Brenda, Gherghiceanu Mihaela, Gottlieb Eyal, Arad Michael, Binah Ofer

Abstract excerpt

LMNA-related dilated cardiomyopathy is an inherited heart disease caused by mutations in the LMNA gene encoding for lamin A/C. The disease is characterized by left ventricular enlargement and impaired systolic function associated with conduction defects and ventricular arrhythmias. We hypothesized that LMNA-mutated patients' induced Pluripotent Stem Cell-derived cardiomyocytes (iPSC-CMs) display...

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Identifiers

PMID: 34360639
DOI: 10.3390/ijms22157874
PMCID: PMC8346174

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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