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Article

Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase.

EMBO reports - 1 Mar 2005

Terai Kenta, Matsuda Michiyuki

Abstract excerpt

A key signalling molecule, c-Raf, is situated downstream from Ras and upstream from the mitogen-activated protein kinase kinase (MEK). We studied the mechanism underlying the signal transduction from Ras to MEK by using probes based on the principle of fluorescence resonance energy transfer. In agreement with previous models, it was found that c-Raf adopted two conformations: open active and closed inactive. Ras...

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Identifiers

PMID: 15711535
DOI: 10.1038/sj.embor.7400349
PMCID: PMC1299259

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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