Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrity and regeneration of mechanotransduction machinery regulate aminoglycoside entry and sensory cell death.

PloS one - 1 Jan 2013

Vu Andrew A, Nadaraja Garani S, Huth Markus E, Luk Lauren, Kim John, Chai Renjie, Ricci Anthony J, Cheng Alan G

Abstract excerpt

Sound perception requires functional hair cell mechanotransduction (MET) machinery, including the MET channels and tip-link proteins. Prior work showed that uptake of ototoxic aminoglycosides (AG) into hair cells requires functional MET channels. In this study, we examined whether tip-link protei...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aminoglycosides
Share to Cadherins
Share to Calcium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Death

Share to Chelating Agents

Share to Egtazic Acid

Share to Hair Cells, Auditory

Share to Mechanotransduction, Cellular

Source

Open in PubMed Open full text

Identifiers

PMID: 23359017
DOI: 10.1371/journal.pone.0054794
PMCID: PMC3554584

Genes

MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23359017-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrity and regeneration of mechanotransduction machinery regulate aminoglycoside entry and sensory cell death.PMID 23359017Read ↗

Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells.Semantic proximity Read ↗

Cilia-Associated Genes Play Differing Roles in Aminoglycoside-Induced Hair Cell Death in Zebrafish.Semantic proximity Read ↗

Response of mechanosensory hair cells of the zebrafish lateral line to aminoglycosides reveals distinct cell death pathways.Semantic proximity Read ↗

TRPA1-mediated accumulation of aminoglycosides in mouse cochlear outer hair cells.Semantic proximity Read ↗

Loss of Slc4a1b chloride/bicarbonate exchanger function protects mechanosensory hair cells from aminoglycoside damage in the zebrafish mutant persephone.Semantic proximity Read ↗

Tip links in hair cells: molecular composition and role in hearing lossSemantic proximity Read ↗

Increased mitophagy protects cochlear hair cells from aminoglycoside-induced damageSemantic proximity Read ↗

Simultaneous gentamicin-mediated damage and Atoh1 overexpression promotes hair cell regeneration in the neonatal mouse utricleSemantic proximity Read ↗

Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt).Semantic proximity Read ↗

Conductance and block of hair-cell mechanotransducer channels in transmembrane channel-like protein mutants.Semantic proximity Read ↗

L-type voltage-gated calcium channel agonists improve hearing loss and modify ribbon synapse morphology in the zebrafish model of Usher Syndrome Type 1Semantic proximity Read ↗

Defining the Cellular Environment in the Organ of Corti following Extensive Hair Cell Loss: A Basis for Future Sensory Cell Replacement in the CochleaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.