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Article

TRPA1-mediated accumulation of aminoglycosides in mouse cochlear outer hair cells.

Journal of the Association for Research in Otolaryngology : JARO - 1 Dec 2011

Stepanyan Ruben S, Indzhykulian Artur A, Vélez-Ortega A Catalina, Boger Erich T, Steyger Peter S, Friedman Thomas B, Frolenkov Gregory I

Abstract excerpt

Aminoglycoside ototoxicity involves the accumulation of antibiotic molecules in the inner ear hair cells and the subsequent degeneration of these cells. The exact route of entry of aminoglycosides into the hair cells in vivo is still unknown. Similar to other small organic cations, aminoglycosides could be brought into the cell by endocytosis or permeate through large non-selective cation channels, such as...

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Identifiers

PMID: 21879401
DOI: 10.1007/s10162-011-0288-x
PMCID: PMC3214240

Genes

TRPA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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