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Article

Silencing of mutant p53 by siRNA induces cell cycle arrest and apoptosis in human bladder cancer cells.

World journal of surgical oncology - 28 Jan 2013

Zhu Hai-Bin, Yang Kai, Xie Yan-Qi, Lin Yi-Wei, Mao Qi-Qi, Xie Li-Ping

Abstract excerpt

BACKGROUND: p53 is the most frequently mutated tumor-suppressor gene in human cancers. It has been reported that mutations in p53 result not only in the loss of its ability as a tumor suppressor, but also in the gain of novel cancer-related functions that contribute to oncogenesis. The present study evaluated the potential of silencing of mutant p53 by small interfering RNA in the treatment of bladder cancer...

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Share to Cell Cycle Checkpoints
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Silencing

Share to Real-Time Polymerase Chain Reaction

Share to RNA, Small Interfering

Share to Tumor Cells, Cultured

Share to Tumor Suppressor Protein p53

Share to Urinary Bladder Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 23356234
DOI: 10.1186/1477-7819-11-22
PMCID: PMC3565885

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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