Article
p53 and chemosensitivity in bladder cancer.
International journal of clinical oncology - 1 Aug 2008
Nishiyama Hiroyuki, Watanabe Jun, Ogawa Osamu
Abstract excerpt
Urothelial carcinoma is the second most common genitourinary malignancy. Although the majority of patients present with superficial bladder tumors, there are several clinical problems, such as progression to invasive tumors, poor prognosis of invasive tumors, and chemosensitivity. Alterations in p53 represent one of the most common genetic events in patients with invasive urothelial carcinoma and are suggested to...
Topics
- Apoptosis
- Carcinoma, Transitional Cell
- Disease Progression
- Drug Resistance, Neoplasm
- Genes, p53
- Humans
- Mutation
- Urinary Bladder Neoplasms
