Article
p53 Mutation in bladder cancer patients in Japan and inhibition of growth by in vitro adenovirus-mediated wild-type p53 transduction in bladder cancer cells.
Molecular urology - 1 Jan 2001
Irie A, Uchida T, Ishida H, Matsumoto K, Iwamura M, Baba S
Abstract excerpt
BACKGROUND: Altered expression of p53 has been described in nearly half of bladder cancers, and p53 mutations are presumed to play a role in the multistep progression of these tumors. MATERIALS AND METHODS: The incidence of mutation in the p53 gene and its correlation with histopathologic findings and patient survival were evaluated in 105 Japanese patients with bladder cancer. Laboratory experiments were also...
Topics
- Adenoviridae
- Apoptosis
- Cell Division
- Cell Separation
- Dose-Response Relationship, Drug
- Flow Cytometry
- Genes, p53
- Genetic Therapy
- Genetic Vectors
- Humans
- Japan
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational