Article
Synthetic small inhibiting RNAs: efficient tools to inactivate oncogenic mutations and restore p53 pathways.
Proceedings of the National Academy of Sciences of the United States of America - 12 Nov 2002
Martinez Luis Alfonso, Naguibneva Irina, Lehrmann Heike, Vervisch Arlette, Tchénio Thierry, Lozano Guillermina, Harel-Bellan Annick
Abstract excerpt
Single base pair mutations that alter the function of tumor suppressor genes and oncogenes occur frequently during oncogenesis. The guardian of the genome, p53, is inactivated by point mutation in more than 50% of human cancers. Synthetic small inhibiting RNAs (siRNAs) can suppress gene expression in mammalian cells, although their degree of selectivity might be compromised by an amplification mechanism. Here, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.