Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Histone deacetylase inhibitor trichostatin A inhibits the growth of bladder cancer cells through induction of p21<sup>WAF1</sup> and G<sub>1</sub> cell cycle arrest

1 May 2006

Abstract excerpt

PURPOSE: To investigate whether Trichostatin A (TSA) possesses antitumor activity against human bladder cancer cells, and if any, its mechanism. MATERIALS AND METHODS: A human bladder cancer cell line, BIU-87, was treated with different concentrations of TSA. After treatment, cell growth was measured by MTT assay. Cell apoptosis and cell cycle changes were examined by means of flow cytometry (FCM). Apoptosis was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Histone Deacetylase Inhibitors Research
Share to Protein Tyrosine Phosphatases
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16771729
DOI: 10.1111/j.1442-2042.2006.01344.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Histone deacetylase inhibitor trichostatin A inhibits the growth of bladder cancer cells through induction of p21<sup>WAF1</sup> and G<sub>1</sub> cell cycle arrestPMID 16771729Read ↗

The Histone Deacetylase Inhibitor Trichostatin A Synergistically Resensitizes a Cisplatin Resistant Human Bladder Cancer Cell LineSemantic proximity Read ↗

Effect of trichostatin A on cell growth and expression of cell cycle- and apoptosis-related molecules in human gastric and oral carcinoma cell linesSemantic proximity Read ↗

The histone deacetylase inhibitor trichostatin A induces cell cycle arrest and apoptosis in colorectal cancer cells via p53-dependent and -independent pathways.Semantic proximity Read ↗

A Histone Deacetylase Inhibitor, Trichostatin A, Enhances Radiosensitivity by Abrogating G2/M Arrest in Human Carcinoma CellsSemantic proximity Read ↗

Histone deacetylase inhibitor-induced cell death in bladder cancer is associated with chromatin modification and modifying protein expression: A proteomic approachSemantic proximity Read ↗

Attenuated DNA Damage Repair by Trichostatin A through BRCA1 SuppressionSemantic proximity Read ↗

Silencing of mutant p53 by siRNA induces cell cycle arrest and apoptosis in human bladder cancer cells.Semantic proximity Read ↗

Prima-1 induces apoptosis in bladder cancer cell lines by activating p53.Semantic proximity Read ↗

Effect of siRNA targeting EZH2 on cell viability and apoptosis of bladder cancer T24 cells.Semantic proximity Read ↗

Gene expression profiling after treatment with the histone deacetylase inhibitor trichostatin A reveals altered expression of both pro- and anti-apoptotic genes in pancreatic adenocarcinoma cellsSemantic proximity Read ↗

Cell cycle kinetics, apoptosis rates, DNA damage and TP53 gene expression in bladder cancer cells treated with allyl isothiocyanate (mustard essential oil).Semantic proximity Read ↗

Histone deacetylase inhibitors induce G2-checkpoint arrest and apoptosis in cisplatinum-resistant ovarian cancer cells associated with overexpression of the Bcl-2-related protein Bad.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.