Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Decreased caspase 3 expression and cytotoxic T lymphocyte antigen-4 polymorphism in Chilean patients with type 1 diabetes].

Revista medica de Chile - 1 Sept 2012

Angel Bárbara B, Codner Ethel, Arredondo Miguel O, Salas Francisca P, Pizarro Carolina A, Pérez Francisco B

Abstract excerpt

BACKGROUND: Several polymorphisms of the CTLA4 gene have been associated with autoimmune diseases. The activation of induced cell death is the major event and caspase 3 represents the main protein for the apoptotic machinery, especially in lymphocytes. AIM: To correlate CTLA4 polymorphisms with caspase 3 expression in peripheral blood mononuclear cells (PBMC) simulating in vitro the glucose effect. MATERIAL AND...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caspase 3

Share to CTLA-4 Antigen

Share to Diabetes Mellitus, Type 1

Share to Leukocytes, Mononuclear

Share to Polymorphism, Genetic

Share to Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 23354631
DOI: 10.4067/S0034-98872012000900002

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Decreased caspase 3 expression and cytotoxic T lymphocyte antigen-4 polymorphism in Chilean patients with type 1 diabetes].PMID 23354631Read ↗

CTLA-4 +49 A/G polymorphism is associated with predisposition to type 1 diabetes in Iranians.Semantic proximity Read ↗

Association of CTLA-4 polymorphisms and clinical-immunologic characteristics at onset of type 1 diabetes mellitus in children.Semantic proximity Read ↗

Immune-mediated beta-cell destruction in vitro and in vivo-A pivotal role for galectin-3.Semantic proximity Read ↗

Interactions between programmed death 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) gene polymorphisms in type 1 diabetes.Semantic proximity Read ↗

Cytotoxic T-lymphocyte antigen-4 +49A/G polymorphisms in Sudanese adults with type 1 diabetes and latent autoimmune diabetes.Semantic proximity Read ↗

[Association between type 1 diabetes and polymorphism of the CTLA-4 gene in a Tunisian population].Semantic proximity Read ↗

Significantly association of diabetes mellitus with CTLA-4 gene polymorphisms based on a meta-analysis of epidemiological evidence in Asians and non-Asians.Semantic proximity Read ↗

TIM-3 polymorphisms in type 1 diabetes families.Semantic proximity Read ↗

Markers for risk of type 1 diabetes in relatives of Alsacian patients with type 1 diabetes.Semantic proximity Read ↗

The importance of CTLA-4 polymorphism and human leukocyte antigen genotype for the induction of diabetes-associated cytokine response in healthy school children.Semantic proximity Read ↗

CTLA-4 (+49A/G) polymorphism and type-1 diabetes in Turkish children.Semantic proximity Read ↗

Toll-like receptor 3 gene polymorphisms in South African Blacks with type 1 diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.