Article
Genetic Determinants of Radiosensitivity: Evidence of Radioresistance-Associated SNP Enrichment in Occupational Workers Chronically Exposed to Low-Dose Radiation.
Genes - 3 Feb 2026
Botbayev Dauren, Sharipov Kamalidin, Belkozhayev Ayaz, Alzhanuly Bakhytzhan, Yerkinbek Ulbossyn, Sharipov Daulet, Gulyayev Alexandr, Kairgeldina Sayagul, Tekebayev Kanat, Zhunussova Gulnur, Baurzhan Madina
Abstract excerpt
Background: Interindividual radiosensitivity is largely driven by genetic regulation of DNA damage recognition, repair, and cell-cycle control. TP53 and CDKN1A (p21) are key genomic markers associated with differential responses to ionizing radiation. Methods: This study investigated eight functional SNP markers across several key genes involved in DNA damage responses and cellular stress regulation, including...
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