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Article

GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression.

Nature cell biology - 1 Feb 2013

Chou Jonathan, Lin Jeffrey H, Brenot Audrey, Kim Jung-whan, Provot Sylvain, Werb Zena

Abstract excerpt

Despite advances in our understanding of breast cancer, patients with metastatic disease have poor prognoses. GATA3 is a transcription factor that specifies and maintains mammary luminal epithelial cell fate, and its expression is lost in breast cancer, correlating with a worse prognosis in human patients. Here, we show that GATA3 promotes differentiation, suppresses metastasis and alters the tumour...

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Source

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Identifiers

PMID: 23354167
DOI: 10.1038/ncb2672
PMCID: PMC3660859

Genes

GATA3
ANGPTL4
ITGA6
ITGB1
LOX
MMP9
VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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