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Article

Targeting the Metastatic Bone Microenvironment by MicroRNAs

27 Apr 2018

Abstract excerpt

Bone metastases are a common and devastating feature of late-stage breast cancer. Metastatic bone disease is a consequence of disturbed bone remodeling due to pathological interactions between cancer cells and the bone microenvironment (BME). In the BME, breast cancer cells severely alter the balanced bone formation and bone resorption driven by osteoblasts and osteoclasts. The complex cellular cross talk in the...

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PMID: 29780354
DOI: 10.3389/fendo.2018.00202

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