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Article

Solution structure of a paradigm ArsR family zinc sensor in the DNA-bound state.

Proceedings of the National Academy of Sciences of the United States of America - 27 Oct 2009

Arunkumar Alphonse I, Campanello Gregory C, Giedroc David P

Abstract excerpt

Staphylococcus aureus CzrA is a zinc-dependent transcriptional repressor from the ubiquitous ArsR family of metal sensor proteins. Zn(II) binds to a pair of intersubunit C-terminal alpha5-sensing sites, some 15 A distant from the DNA-binding interface, and allosterically inhibits DNA binding. This regulation is characterized by a large allosteric coupling free energy (DeltaGc) of approximately +6 kcal mol(-1),...

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PMID: 19822742
DOI: 10.1073/pnas.0905558106
PMCID: PMC2775347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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