Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variants in the 15q24/25 locus associate with lung function decline in active smokers.

PloS one - 1 Jan 2013

Mohamed Hoesein Firdaus A A, Wauters Els, Janssens Wim, Groen Harry J M, Smolonska Joanna, Wijmenga Cisca, Postma Dirkje S, Boezen H Marike, De Jong Pim A, Decramer Marc, Lammers Jan-Willem J, Lambrechts Diether, Zanen Pieter

Abstract excerpt

Genetic variation in nicotinic acetylcholine receptor subunit genes (nAChRs) is associated with lung function level and chronic obstructive pulmonary disease (COPD). It is unknown whether these variants also predispose to an accelerated lung function decline. We investigated the association of nAChR susceptibility variants with lung function decline and COPD severity. The rs1051730 and rs8034191 variants were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 15
Share to Lung
Share to Nicotine
Share to Protein Subunits
Share to Pulmonary Disease, Chronic Obstructive
Share to Receptors, Nicotinic
Share to Smoking
Share to Substance-Related Disorders

Source

Open in PubMed Open full text

Identifiers

PMID: 23349703
DOI: 10.1371/journal.pone.0053219
PMCID: PMC3548843

Genes

FEV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variants in the 15q24/25 locus associate with lung function decline in active smokers.PMID 23349703Read ↗

The 15q24/25 susceptibility variant for lung cancer and chronic obstructive pulmonary disease is associated with emphysema.Semantic proximity Read ↗

Nicotinic acetylcholine receptor variants associated with susceptibility to chronic obstructive pulmonary disease: a meta-analysis.Semantic proximity Read ↗

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25.Semantic proximity Read ↗

A functional polymorphism in the CHRNA3 gene and risk of chronic obstructive pulmonary disease in a Korean population.Semantic proximity Read ↗

Chr15q25 genetic variant (rs16969968) independently confers risk of lung cancer, COPD and smoking intensity in a prospective study of high-risk smokers.Semantic proximity Read ↗

Four SNPs in the CHRNA3/5 alpha-neuronal nicotinic acetylcholine receptor subunit locus are associated with COPD risk based on meta-analyses.Semantic proximity Read ↗

Chr15q25 Genetic Variant rs16969968 Alters Cell Differentiation in Respiratory Epithelia.Semantic proximity Read ↗

Gene variance in the nicotinic receptor cluster (CHRNA5-CHRNA3-CHRNB4) predicts death from cardiopulmonary disease and cancer in smokers.Semantic proximity Read ↗

Role of CHRNA5-A3 genetic Locus variants and developing drug for chronic obstructive pulmonary disease.Semantic proximity Read ↗

A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci.Semantic proximity Read ↗

Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-Americans.Semantic proximity Read ↗

Nicotinic acetylcholine receptor variants are related to smoking habits, but not directly to COPD.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.