Article
Activation of islet autoreactive naïve T cells in infants is influenced by homeostatic mechanisms and antigen-presenting capacity.
Diabetes - 1 Jun 2013
Heninger Anne-Kristin, Monti Paolo, Wilhelm Carmen, Schwaiger Petra, Kuehn Denise, Ziegler Anette-G, Bonifacio Ezio
Abstract excerpt
Islet autoimmunity precedes type 1 diabetes onset. We previously found that islet autoimmunity rarely starts before 6 months of age but reaches its highest incidence already at ∼1 year of age. We now examine whether homeostatic expansion and immune competence changes seen in a maturating immune system may account for this marked variation in islet autoimmunity risk in the first year of life. We found naïve...
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