Article
SLC2A9 Genotype Is Associated with SLC2A9 Gene Expression and Urinary Uric Acid Concentration.
PloS one - 1 Jan 2015
Ware Erin B, Riehle Ellen, Smith Jennifer A, Zhao Wei, Turner Stephen T, Kardia Sharon L R, Lieske John C
Abstract excerpt
OBJECTIVES: SLC2A9 gene variants have been associated with urinary uric acid (UA) concentration, but little is known about the functional mechanism linking these gene variants with UA. SLC2A9 encodes a UA transporter present in the proximal tubule of the kidney, and gene expression levels of SLC2A9 and other genes in the uricosuric pathway (ABCG2, SLC17A1, SLC17A3, and SLC22A12) could potentially mediate the...
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