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Salmonella spvC Gene Inhibits Pyroptosis and Intestinal Inflammation to Aggravate Systemic Infection in Mice

15 Dec 2020

Abstract excerpt

Salmonella enterica serovar Typhimurium ( S ). Typhimurium is a primary foodborne pathogen infecting both humans and animals. Salmonella plasmid virulence C ( spvC ) gene is closely related to S . Typhimurium dissemination in mice, while the mechanisms remain to be fully elucidated. Pyroptosis, a gasdermin-mediated inflammatory cell death, plays a role in host defense against bacterial infection, whereas the...

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PMID: 33384666
DOI: 10.3389/fmicb.2020.562491

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