Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ambra1 knockdown in zebrafish leads to incomplete development due to severe defects in organogenesis.

Autophagy - 1 Apr 2013

Benato Francesca, Skobo Tatjana, Gioacchini Giorgia, Moro Isabella, Ciccosanti Fabiola, Piacentini Mauro, Fimia Gian Maria, Carnevali Oliana, Dalla Valle Luisa

Abstract excerpt

AMBRA1 is a positive regulator of the BECN1-dependent program of autophagy recently identified in mouse. In this study, we cloned the full-length cDNAs of ambra1a and ambra1b zebrafish paralogous genes. As in mouse, both Ambra1 proteins contain the characteristic WD40 repeat region. The transcripts of both genes are present as maternal RNAs in the eggs and display a gradual decline until 8 hpf, being replaced by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy
Share to Embryo, Nonmammalian

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Embryonic Development

Share to Gene Knockdown Techniques

Share to Morpholinos

Share to Organogenesis

Share to Synteny

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23348054
DOI: 10.4161/auto.23278
PMCID: PMC3627665

Genes

AMBRA1
BECN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ambra1 knockdown in zebrafish leads to incomplete development due to severe defects in organogenesis.PMID 23348054Read ↗

Zebrafish ambra1a and ambra1b Knockdown Impairs Skeletal Muscle DevelopmentSemantic proximity Read ↗

Ambra1 regulates autophagy and development of the nervous system.Semantic proximity Read ↗

Rare mutations in the autophagy‐regulating gene AMBRA1 contribute to human neural tube defectsSemantic proximity Read ↗

A novel role for autophagy in neurodevelopment.Semantic proximity Read ↗

Biallelic variants in LARS1 induce steatosis in developing zebrafish liver via enhanced autophagySemantic proximity Read ↗

Development and Characterization of a larp7 Knockout Zebrafish Model for Alazami syndromeSemantic proximity Read ↗

zmiz1a zebrafish mutants have defective erythropoiesis, altered expression of autophagy genes, and a deficient response to vitamin D.Semantic proximity Read ↗

Zebrafish as a model to study autophagy and its role in skeletal development and diseaseSemantic proximity Read ↗

Modulation of autophagy influences development and apoptosis in mouse embryos developing in vitroSemantic proximity Read ↗

Characterization of the 38 kDa protein lacking in gastrula-arrested mutant Xenopus embryos.Semantic proximity Read ↗

Distinct roles of core autophagy-related genes in zebrafish definitive hematopoiesis.Semantic proximity Read ↗

Leucyl-tRNA Synthetase Deficiency Systemically Induces Excessive Autophagy in ZebrafishSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.