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Article

Zebrafish ambra1a and ambra1b Knockdown Impairs Skeletal Muscle Development

12 Jun 2014

Abstract excerpt

The essential role of autophagy in muscle homeostasis has been clearly demonstrated by phenotype analysis of mice with muscle-specific inactivation of genes encoding autophagy-related proteins. Ambra1 is a key component of the Beclin 1 complex and, in zebrafish, it is encoded by two paralogous genes, ambra1a and ambra1b, both required for normal embryogenesis and larval development. In this study we focused on...

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PMID: 24922546
DOI: 10.1371/journal.pone.0099210

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